Project 2 CellCAD

Project 2   CellCAD

Engineering is about building things, but so is tinkering, and part of what sets them apart is that engineering employs predictive models as design tools. To make cell biology into engineering, we seek to harness quantitative models of organelle and cell dynamics to build design software that will help guide decisions about genetic modifications, including gene knockouts and expression of interaction-driving constructs. The output will be a constellation of candidate molecular changes to be implemented using the tools of the Cellular Machine Shop. We envision two approaches: (1) A model-driven strategy in which we use coarse grained theoretical models for organelle dynamics to build design tools by applying control theory concepts to the organelle models, and (2) a data-driven strategy in which we use large datasets as the basis for empirical predictors built with machine learning methods